| 大鼠红细胞免疫功能低下模型的研究 |
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| 引用本文： | 杨运高,陈先明,傅江南,周登峰,江海燕. 大鼠红细胞免疫功能低下模型的研究[J]. 中国中医基础医学杂志, 2002, 8(3): 44-46 |
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| 作者姓名： | 杨运高 陈先明 傅江南 周登峰 江海燕 |
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| 作者单位： | 第一军医大学,中医系,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金资助项目 (No.30 0 70 937) |
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| 摘 要： | 目的：研究红细胞免疫缺陷动物模型。方法：大鼠采用低硒饲料喂养13周，观察红细胞免疫功能以及氧化抗氧化功能的变化情况。结果：第8周时，模型组动物红细胞免疫功能发生紊乱，以E-C3bR和E-ACCR低下为主。至第13周时更为明显，红细胞免疫黏附功能明显下降，E-IC含量明显增高。与此同时，红细胞氧化和抗氧化功能也发生明显变化，SOD、GSH-PX活性下降，MDA含量上升。结论：13周时，该模型表现为明显的红细胞免疫功能缺陷。
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| 关 键 词： | 红细胞免疫 动物模型 |
| 文章编号： | 1006-3250(2002)03-0044-03 |
| 修稿时间： | 2001-09-12 |
Study on the Model of rats on the Hypoimmunity of the Erythrocyte |
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| YANG Yun gao,CHEN Xian ming,FU Jiang nan,et al.. Study on the Model of rats on the Hypoimmunity of the Erythrocyte[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2002, 8(3): 44-46 |
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| Authors: | YANG Yun gao CHEN Xian ming FU Jiang nan et al. |
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| Abstract: | Objective:To investigate the Model of rats on the Hypoimmunity of the erythrocyte. Methods:rats were fed by low Selenium diet for 13 weeks. the number of erythrocyte C 3b receptor rosette, immune complex rosette and erythrocyte immune adherence cancer receptor rosette of the model were tested. Results:erythrocyte C 3b receptor rosette, erythrocyte immune adherence cancer receptor rosette, SOD and GSH PX of rats decreased but erythrocyte immune complex rosette and MDA increased significantly in the rats. Conclusion:erythrocytoimmunity function of the rats were changed significantly fed by low Selenium diet for 13 weeks. |
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| Keywords: | erythrocytoimmunity Animal model |
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