彩色多普勒超声对门脉高压犬模型建立前后血流动力学的研究

目的　应用超声显像及多普勒技术研究犬肝前性门脉高压症模型的血流动力学改变及其发生机制。方法　通过行缩窄门静脉主干 1 2加丝线慢性栓塞术建立犬肝前性门脉高压症模型 ,于模型建立术前和术后各进行一次二维超声及彩色多普勒血流显像 (CDFI)检查。结果　超声检测显示①术后门静脉系统血管内径均较术前明显增宽 ;②实验犬有广泛门体分流形成 ;③门静脉、肠系膜上静脉流速减慢 ,流量无显著改变 ,脾门脾静脉流速减慢 ,流量增加 ,肝动脉流速增快 ,流量增加。结论　该模型犬术后出现显著血流动力学改变 ,适应于急性血流动力学实验研究

The canines study of hemodynamics about portal hypertension by color Doppler ultrasound before and after operation

Objective To study the hemodynamics changes and mechanism of prehepatic portal hypertension(PHT) canines. Methods Prehepatic PHT canine models were made by squeezing main portal vein with silk line chronic embolization. Prehepatic PHT canines were examined the hemodynamics changes by color Doppler ultrasound before and after operation. Results Color Doppler ultrasound indicated that portal venous system vessel diameters were definitely wider than that of before operation. Prehepatic PHT canines showed a high portal systemic shunting (PSS).The Vmax of portal vein and superior mesenteric vein reduced significantly and the BFV of which had no significant changes. The Vmax for splenic vein reduced and the BFV increased significantly. For hepatic artery,both the Vmax and BFV increased. Conclusion Prehepatic PHT canines showed remarkable hemodynamics changes which can be used for experimental study .