塞来昔布的药理作用、药代动力学及临床评价

目的:评价特异性环氧酶抑制剂——塞来昔布的药理作用、药代动力学及临床疗效。方法:评述国内、外近期有关塞来昔布的文献。结果:推荐剂量的塞来昔布治疗骨关节炎和风湿性关节炎疗效与传统的非甾体抗炎药物(NSAIDs)相似,疗效确切,但较少引起胃肠道溃疡,且不延长出血时间,耐受性良好。结论:塞来昔布与目前国内、外广泛应用的NSAIDs相比,疗效确切,降低了胃肠道损伤的发生率,与治疗高血压、糖尿病等药物联用,没有明显的药物相互作用。

Evaluation of the Pharmacological Action, Pharmacokinetics and Clinical Efficacy of Celecobix

OBJECTIVE: To evaluate the pharmacological action, pharmacokinetics and therapeutic efficacy of Celecobix, a specific epioxidase inhibiting agent .METHODS: To review the relevent literature reported at home and abroad in recent years.RESULTS: The therapeutic effects of Celecobix in recommended dosage on osteoarthritis and rheumatic arthritis were comparable to those of traditional NSAIDs, and Celecobix induced less gastroenteric ulcers, did not prolong the bleeding time and was tolerable to patients.CONCLUSION: Compared with NSAIDs which are extensively used at home and abroad, Celecobix is satisfactory in therapeutic effect and can reduce the incidence of gastroenteric ulcers,moreover,it does not interact with the drugs for hypertension or diabetes.