The distribution of amino acids between erythrocytes and plasma in fetal and maternal blood |
| |
| Authors: | K B Bj?renesj? |
| |
| Affiliation: | 1. Research Unit of Obstetrics and Gynecology, Department of Clinical Research, University of Southern Denmark, Kløvervænget 10, 10th floor, 5000 Odense C, Denmark;2. Odense Patient Data Explorative Network (OPEN), Department of Clinical Research, University of Southern Denmark and Odense University Hospital, J.B. Winsløws Vej 9a 3rd floor, 5000 Odense C, Denmark;3. Department of Public Health, Biostatistics, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, Denmark;4. Division of Nutritional Sciences, Cornell University, 111 Savage Hall Ithaca, NY 14853, USA;5. Division of Research, Cardiovascular and Metabolic Conditions Section, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA;6. Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark;7. Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark;8. Department of Gynecology and Obstetrics, Odense University Hospital, Sdr. Boulevard 55, 5000 Odense C, Denmark;1. Department of Toxicology, Anhui Medical University, China;2. Anhui Provincial Key Laboratory of Population Health & Aristogenics, China |
| |
| Abstract: | The concentrations of most free amino acids in red cells increase during pregnancy simultaneously with a decrease in the plasma amino acids, which results in significantly higher erythrocyte/plasma distribution ratios at delivery for all amino acid groups studied except threonine + glutamic acid. The plasma amino acids are significantly higher in fetal than in maternal plasma. Thus an active transport of amino acids through the placenta against a concentration gradient and an increased cellular uptake of amino acids both contribute to the low plasma amino acid values found in pregnancy.All amino acid groups studied in pregnant females at delivery show significantly higher distribution ratios than simultaneous blood specimens from the fetus. The erythrocyte/plasma amino acid ratios in fetal blood are similar to those found in non-pregnant females. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
