肾移植排斥反应的生物学标志物

尿毒症是各种肾病终末期的转归,肾移植术是目前治疗尿毒症的最佳方案,但由于不同个体免疫组织相容性复合物不同,往往在移植术后发生各种类型的排斥反应,严重影响移植肾的功能和受者的生活质量,所以临床需要一种高特异性、高敏感性的生物学标志物早期预示排斥反应发生的高危性,从而让临床医生能够更改治疗方案,避免移植物的损害。近些年,越来越多的关于这类生物学标志物的研究已经开展。

Biological markers of rejections in renal transplantation

Uremia is the terminal outcome of all kinds of nephropathy. Renal transplantation is the best solution in the treatments of uremia. However, due to different individual immune histocompatibility, different types of rejection may occur after transplantation which would severely affect the life quality of recipients and the function of transplant kidney. So, biological markers with high specificity and sensitivity are clinically called to indicate the risk of rejections at early phase. In that case, physicians can change their treatments so as to protect transplants. In recent years, more and more researches on this field have been carried out.