小儿肺炎血清粒细胞集落刺激因子、可溶性白细胞介素受体、C反应蛋白水平的变化及意义

目的探讨小儿肺炎患者血清中粒细胞集落刺激因子（G-CSF）、可溶性白细胞介素受体（sIL-2R）、C反应蛋白（CRP）水平的变化及意义。方法 60例小儿肺炎患者为观察组,其中病毒性肺炎20例（病毒性肺炎组）、支原体肺炎20例（支原体肺炎组）、细菌性肺炎20例（细菌性肺炎组）。选择30例健康体检儿童为对照组。全自动生化分析仪测定血清中CRP水平;ELISA法检测血清中sIL-2R、G-CSF水平。比较不同病原体感染肺炎患儿血清sIL-2R、CRP含量;比较不同年龄肺炎患儿血清G-CSF阳性率;分析肺炎患儿体温与血清G-CSF水平关系。结果支原体肺炎组、细菌性肺炎组、病毒性肺炎组患儿血清sIL-2R、CRP水平均明显高于对照组。支原体肺炎组、细菌性肺炎组血清CRP水平明显高于病毒肺炎组,细菌性肺炎组血清CRP水平明显高于支原体肺炎组。60例肺炎患儿血清G-CSF阳性率为61.7%,其中1~2岁患儿的血清G-CSF阳性率最高。60例患儿中发热患儿血清G-CSF阳性率明显高于非发热患儿。结论测定血清中G-CSF、sIL-2R、CRP水平有助于小儿肺炎的诊断。

Changes and significance of serum granulocyte colony stimulating factor,soluble interleukin receptor and C-reactive protein in children with infantile pneumonia

Objective To explore the changes and significance of serum granulocyte colony stimulating factor（G-CSF）, soluble interleukin receptor（sIL-2R）and C-reactive protein（CRP）in children with infantile pneumonia.Methods 60 children with infantile pneumonia were collected and designed as observation group. They were divided into viral pneumonia group, mycoplasma pneumonia group and bacterial pneumonia group, 20 cases in each group. 30 healthy children were collected and designed as control group.Serum CRP level was detected by automatic biochemical analyzer, while sIL-2R and G-CSF levels were detected by ELISA. Contents of serum sIL-2R and CRP in children with different pathogens and positive rate of G-CSF in children with different age were compared. Relationship between body temperature and serum G-CSF level was analyzed.Results Levels of serum sIL-2R and CRP in the viral pneumonia group, mycoplasma pneumonia group and bacterial pneumonia group were significantly higher than those in the control group. Levelsof CRP in the mycoplasma pneumonia group and bacterial pneumonia group were significantly higher than that in the viral pneumonia group, and CRP level in the bacterial pneumonia group was significantly higher than that in the mycoplasma pneumonia group. Positive rate of serum G-CSF in the observation group was 61.7%, and the highest positive rate of serum G-CSF was detected in children with age of 1 to 2. Among the 6 0 children with infantile pneumonia, the positive rateof serum G-CSF in children with fever was significantly higher than that in children without fever.Conclusion Detections of serum G-CSF, sIL-2R and CRP levels are conductive to the diagnosis of children with infantile pneumonia.