| 巴戟天多糖对去卵巢大鼠骨质疏松症的防治作用 |
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| 引用本文： | 刘亦恒,吴多庆,朱振标,黄重,陈晓虹,张海英.巴戟天多糖对去卵巢大鼠骨质疏松症的防治作用[J].海南医学,2014(20):2973-2975. |
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| 作者姓名： | 刘亦恒 吴多庆 朱振标 黄重 陈晓虹 张海英 |
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| 作者单位： | 1. 海口市人民医院骨科中心,海南 海口,570208
2. 海南医学院人体解剖学教研室,海南 海口,571101 |
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| 基金项目： | 海南省自然科学基金(编号811156)；海南省卫生厅资助项目(编号琼卫2010-69)；海口市重点科技项目 |
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| 摘 要： | 目的观察巴戟天多糖对去卵巢大鼠骨质疏松症的影响。方法成年雌性SD大鼠30只，随机分为假手术组、模型组、巴戟天多糖组，每组lO只。采用摘取双侧卵巢法建立骨质疏松模型，造模2周后开始给药，给药3个月后观察巴戟多糖天对大鼠骨密度、骨矿物质含量、血清雌二醇、骨钙素及l，25-二羟基维生素功的影响。结果给药3个月后，与模型组比较，巴戟天多糖组能显著提高去卵巢大鼠的骨密度、骨矿物质、l，25-二羟，基维生素D及骨钙素的含量。结论巴戟天多糖对去卵巢所致的大鼠骨质疏松症具有良好的防治作用。
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| 关 键 词： | 骨质疏松 去卵巢大鼠 巴戟天多糖 |
Protective and therapeutic effects of morindae officinails polysaccharides on osteoporosis of ovariectomized rats |
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| LIU Yi-heng,WU Duo-qing,ZHU Zhen-biao,HUANG Zhong,CHEN Xiao-hong,ZHANG Hai-ying.Protective and therapeutic effects of morindae officinails polysaccharides on osteoporosis of ovariectomized rats[J].Hainan Medical Journal,2014(20):2973-2975. |
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| Authors: | LIU Yi-heng WU Duo-qing ZHU Zhen-biao HUANG Zhong CHEN Xiao-hong ZHANG Hai-ying |
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| Institution: | LIU Yi-heng 1, WU Duo-qing ZHU Zhen-biao , HUANG Zhong , CHEN Xiao-hong , ZHANG Hai-ying ( 1. Depantment of Orthopaedics, Haikou Municipal People＇s Hospital, Haikou 570208, Hainan, CHINA; 2. Department of Anatomy, Hainan Medical College, Haikou 571101, Hainan, CHINA) |
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| Abstract: | Objective To observe the protective and therapeutic effects ofmorindae officinails polysaccha- rides on osteoporosis of ovariectomized rats. Methods Thirty adult female SD rats were divided randomly into sham-operated group, model group, morindae officinails polysaccharides group. Every group had ten rats. We extract- ed bilateral ovaries to establish osteoporosis model, which were treated with medicine two weeks postoperationally for consecutively 3 months. Then we observed the protective and therapeutic effects of morindae o~cinails polysaccha- rides on rat bone mineral density （BMD）, bone mineral content, estrogen, osteocalcin, l, 25-dihydroxyvitamin D3. Results After 3 months, the morindae officinails polysaccharides group could significantly improve the BMD, bone mineral content, osteocalcin, 1, 25-dihydroxyvitamin D3 of the ovariectomized rats, compared with model group. Conclusion Morindae officinails polysaccharides can antagonize osteoporosis of the ovariectomized rats. |
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| Keywords: | Osteoporosis Ovariectomized rats Morindae officinails polysaccharides |
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