慢性乙型肝炎患者血清前Pre-S1抗原检测及其与肝功能关系的研究

目的检测慢性乙型肝炎病毒患者前S1(Pre-S1)抗原,探讨其与肝功能的关系。方法收集270例慢性乙型肝炎病毒患者血清,采用ELISA方法检测Pre-S1抗原;采用AU2700全自动生化分析仪检测丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)。结果 270例慢性乙型肝炎病毒患者中,Pre-S1抗原阳性中ALT异常检出率为91.1%,AST异常检出率为93.0%,Pre-S1抗原中阴性中ALT异常检出率为28.3%,AST异常检出率为35.4%,两组结果有显著性差异(P<0.05)。结论慢性乙型肝炎患者中,Pre-S1抗原可作为判断乙型肝炎病毒(HBV)感染,复制及对肝细胞损伤的另一个指标之一。

Study the Relationship of Pre-S1 Antigen Detection and Liver Function for the Patients of Chronic Hepatitis B Virus

Objective Examine Pre-Sl antigen for the patients of chronic hepatitis B virus, Study the relationship of it and Liver Function. Methods Collect 270 serum samples of chronic hepatitis B virus patients, By ELISA test Pre-S 1 antigen, Hitachi 7170 with automatic biochemical analyzer test alanine aminotransferase （ALT）, aspartate aminotransferase （AST）. Results 270 eases of chronic hepatitis B virus patients, Pre-S1 antigen positive in the abnormal ALT detection rate was 91.1%, AST anomaly detection rate was 93.0%, Pre-S1 antigen negative in the detection rate of abnormal ALT 28.3%, AST anomaly detection rate was 35.4%, two roups of results have the significance difference （P〈 0.05）. Conclusion In patients with chronic hepatitis B virus, Pre-S 1 antigens can be used as a hepatitis B virus （HBV） infection, copy and liver cell injury and another one of the indicators.