| 局灶性幼猪心肌急性缺血再灌时钙超载与形态变化 |
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| 引用本文： | 郭兆贵,罗武生,汤显良,唐外星,刘大冲,王亮,沈明.局灶性幼猪心肌急性缺血再灌时钙超载与形态变化[J].中南大学学报(医学版),1990(3). |
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| 作者姓名： | 郭兆贵 罗武生 汤显良 唐外星 刘大冲 王亮 沈明 |
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| 作者单位： | 湖南医科大学药理研究室
(郭兆贵，罗武生，汤显良)，湖南医科大学电镜室
(唐外星，刘大冲)，湖南医科大学病理教研室
(王亮)，湖南医科大学病理教研室(沈明) |
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| 摘 要： | 在建立幼猪局灶性心肌急性缺血再灌流损伤模型的基础上,着重观察单纯性缺血与缺血后再灌流“钙超载”和病理形态变化。电镜下单纯性缺血与再灌流病变不尽相同,后者病变较严重。焦锑酸盐细胞内钙定位方法表明,再灌流后心肌细胞内钙铬合物明显增多,揭示钙超载可能是引起缺血后再灌流功能失常的原因。
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| 关 键 词： | 冠状动脉疾病 疾病模型 动物 钙 代谢 超微结构 病理生理学 猪 |
CALCIUM OVERLOAD AND HISTOPATHOLOGY IN ACUTE ISCHEMIA AND REPERFUSION OF THE PORCINE HEART |
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| Guo Zhaogui Luo.Wusheng Tang XianliangResearch Section of Pharmacology,Hunan Medical UniversityTang Waixing Liu DachongLaboratory of Electron Microscopy,Hunan Medical UniversityWang Liang Shen Ming.CALCIUM OVERLOAD AND HISTOPATHOLOGY IN ACUTE ISCHEMIA AND REPERFUSION OF THE PORCINE HEART[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1990(3). |
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| Authors: | Guo Zhaogui LuoWusheng Tang XianliangResearch Section of Pharmacology Hunan Medical UniversityTang Waixing Liu DachongLaboratory of Electron Microscopy Hunan Medical UniversityWang Liang Shen Ming |
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| Institution: | Guo Zhaogui Luo.Wusheng Tang XianliangResearch Section of Pharmacology,Hunan Medical UniversityTang Waixing Liu DachongLaboratory of Electron Microscopy,Hunan Medical UniversityWang Liang Shen MingDepartment of Pathology,Hunan Medical University |
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| Abstract: | Calcium overload and histopathology were investigated in the cardiac ischemia and reperfusion damage of the porcine hearts. The ultrastructural chan -ges were different between the ischemia and reperfusion groups with even more severe damage occurred in the later group. Intracellular calcium deposit localized by pyroantimonate method was markedly increased in the reperfused myocardium. It is suggested that calcium overload plays an important role in the cardiac ischemia and reperfusion damage. |
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| Keywords: | coronary heart disease disease models animal calcium metabo- lism physiopathology ultrastructure swine |
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