柔红霉素预防晶状体后囊膜混浊的实验研究

目的：通过动物实验探讨柔工霉素预防白内障术后的后囊膜混浊的作用及临床应用价值。方法：采用柔红霉素5．0μg/ml,7.5μg/ml两种浓度在兔眼晶状体囊外摘除术中行囊袋内灌注5分钟，通过裂隙灯显微镜观察其术后反应。术后3个月取眼球做病理切片观察组织的毒性反应。结果：随访3个月，用药后发障的发生率明显减,水发现角膜，葡萄膜及视网膜的毒性反应。结论：柔红霉素术中一次性囊袋内灌注，可养活后囊混浊的发生率，并对周围组织无损伤，安全，有效，方便使红霉素在混浊预防方面有临床应用价值。

Experiment study of preventing from posterior capsular opacity by daunomycin

Objective To investigate the effect of daunomycin as a preventer of posterior capsule opacification(PCO),and the applicability in clinical procession by animal experiments.Methods To infuse 5.0ug/ml,7.5ug/ml daunomycin into les capsular bag for five minutes during ECCE operation on rabbit eyes(20 cases).The post-operative response of eye tissue was observed under slit lamp microscop.At postoperative 3 months ,the ocular pathological changes was observed by light microscope.Results With three months follow-up,it was found that the incidence of PCO decreased in the drug group,without any cornea or uveitis,retina damage.Conclusions The study indicated that the incidence of PCO could be reduced by single intraocular infusion of daunomycin without toxicity to adjacent ocular tissues.Its efficiency,safety and simplicity sugest that daunomycin can be valuable for the provention of PCO during clinical application.