盐酸舍曲林治疗冠心病患者伴焦虑抑郁状态的疗效

目的 探讨盐酸舍曲林对冠心病患者焦虑、抑郁状态的影响.方法对179例冠心病伴焦虑、抑郁患者随机分为对照组87例和治疗组92例,给予冠心病常规治疗和心理治疗,治疗组同时给予盐酸舍曲林口服,25 mg起服,qd,早餐后服药,第3天加量至50 mg.疗程为8周.分别在治疗2周和治疗8周进行患者焦虑自评量表(SAS)、抑郁自评量表(SDS)、症状自评量表(SCL-90)评分和冠心病临床症状(心电图ST段改变级胸痛等)缓解情况比较.结果治疗8周后,盐酸舍曲林治疗组临床症状好转率(96.7%)较对照组(86.2%)高(P<0.05).治疗2周后和8周后治疗组和对照组SAS、SDS评分均较首次评定显著下降 (P<0.01);且治疗8周盐酸舍曲林治疗组较对照组SAS、SDS评分下降更为明显(P<0.05).SCL-90量表显示患者躯体化、抑郁和焦虑状态在治疗2周和8周均较入院时症状改善明显.结论盐酸舍曲林能明显改善冠心病患者焦虑、抑郁症状,并明显缓解冠心病患者急性期临床症状.

Therapeutic Effect of Sertraline on Patients with Coronary Heart Disease Accompanied by Anxiety and Depression

Objective To investigate sertraline hydrochloride on symptoms of anxiety and depression in patients with coronary heart disease.Methods One hundred and seventy-nine cases with coronary heart disease accompanied by anxiety and depression were randomly divided into control group(87 cases) and intervention group(92 cases).They were given conventional treatment of coronary heart disease and psychological treatment,and at the same time the intervention group was orally administered with sertraline hydrochloride.Clinical symptoms(ECG ST-segment change,the level of chest pain,etc.) and the SAS,SDS,SCL-90 scale scores were evaluated after treatment for 2 weeks and 8 weeks,respectively.Results After 8 weeks of treatment,the clinical symptoms in the intervention group(with sertraline hydrochloride) were alleviated significantly with totally efficiency rate(96.7%) higher than that in the control group(86.2%)(P<0.05).After treatment for 2 weeks and 8 weeks,SAS and SDS scores in the intervention group were significantly decreased as compared with those in the control group(P<0.01).In the intervention group,SAS and SDS scores were decreased significantly as compared with those in the control group(P<0.05) after treatment for weeks.SCL-90 scale result showed that somatization,depression and anxiety status were improved significantly after treatment for 2 weeks and 8 weeks.Conclusion Sertraline can significantly improve anxiety and depression symptoms in patients with coronary heart disease,and significantly alleviate the acute clinical symptoms of patients with coronary heart disease.