Immunostimulant oxidized beta-glucan conjugates |
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Authors: | Cross G G Jennings H J Whitfield D M Penney C L Zacharie B Gagnon L |
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Affiliation: | National Research Council, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6. |
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Abstract: | beta-Glucans are polysaccharides that act as nonspecific immune system stimulants. However, many beta-Glucans are sparingly soluble in water. This work describes an oxidative procedure, which solubilizes the beta-Glucan from Saccharomyces cerevisiae and maintains its immunostimulatory properties. Furthermore, the carboxylates at the site of oxidation allow for the conjugation of small molecule immunostimulants. Both the parent oxidized beta-glucan and its conjugates with O-beta-alanyl-5-[6-(N,N'-dimethylamino)purin-9-yl]pentanol stimulate cytotoxic T-lymphocytes (CTLs), B cells and macrophages. In addition, they both stimulate natural killer (NK) cells, a property which the small molecule purine does not possess. |
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