Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1 |
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Authors: | Ogueh O; Hills FA; Chard T; Johnson MR |
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Institution: | Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK. |
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Abstract: | In animals, dexamethasone administration during pregnancy leads to fetal
growth restriction due to enhanced expression of insulin-like growth factor
binding protein-1 (IGFBP-1). In humans, there is also a significant inverse
correlation between maternal and fetal concentrations of IGFBP-1 and birth
weight. During pregnancy, maternal IGFBP-1 is derived from the decidualized
endometrium. We have studied the effect of dexamethasone on circulating
concentrations of IGFBP-1 in 12 pregnant women who received dexamethasone
therapy for fetal lung maturation in anticipation of premature delivery
before 34 completed weeks of gestation. Blood samples were collected before
dexamethasone administration, at 24 h and 48 h after the course of
dexamethasone, and within 24 h of delivery, for the measurement of IGFBP-1.
There was no significant change in plasma IGFBP-1 concentrations at 24 and
48 h following dexamethasone therapy, and at delivery (P = 0.666, 0.307 and
0.398, respectively). Therefore, antenatal dexamethasone therapy does not
influence decidual synthesis of IGFBP-1.
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