Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury |
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Authors: | Mark K Lyons Robert E Anderson Fredric B Meyer |
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Institution: | Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905. |
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Abstract: | This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity. |
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Keywords: | Corticotropin-releasing factor Neuron Antagonist Electroencephalogram Ischemia Hippocampus |
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