| 低硒高镉对大鼠心肌损伤作用的研究 |
| |
| 引用本文： | 王爱国 陈学敏. 低硒高镉对大鼠心肌损伤作用的研究[J]. 中华预防医学杂志, 1994, 28(2): 94-96 |
| |
| 作者姓名： | 王爱国 陈学敏 |
| |
| 作者单位： | 同济医科大学环境卫生学教研室 |
| |
| 摘 要： | 用控制硒、镉含量的饲料喂养生长期ＳＤ大鼠，观察低硒和高镉对大鼠心肌的损伤作用。结果表明：低硒和高镉可引起大鼠心肌的灶状坏死，对心肌和心肌膜系统均有不同程度的损伤作用，心肌的谷胱甘肽过氧化物酶和细胞色素氧化酶的活性下降。提示克山病区粮中存在损伤大鼠心肌的因素，补硒可防止病区粮所致的心肌损伤。
|
| 关 键 词： | 硒，镉；心肌疾病 |
Studies on the Effects of Low-dose selenium and High-dose Cadmium on Myocardial Injury |
| |
| Wang Ai-guo,Chen Xue-min,Lu Wen-qing,et al.. Studies on the Effects of Low-dose selenium and High-dose Cadmium on Myocardial Injury[J]. Chinese Journal of Preventive Medicine, 1994, 28(2): 94-96 |
| |
| Authors: | Wang Ai-guo Chen Xue-min Lu Wen-qing et al. |
| |
| Affiliation: | Wang Ai-guo,Chen Xue-min,Lu Wen-qing,et al., |
| |
| Abstract: | he effects of low-dose selenium and high-dose cadmium on myocardial injury were studied in weanling S.D. rats fed with feed containing controlled levels of selenium and cadmium. Results indi-cated low-dose selenium and high-dose cadmium could injure heart and myocardial cell membrane sys-tem to a certain extent,and cause focal necrosis and reduction in activities of glutathione peroxidase and cytochrome oxidase of heart muscle in rats.It suggested there were eertain factors in the grain pro-duced in the areas where Keshan disease was prevalent,which imjured heart muscle in rats.So,selenium supplement could prevent from myocardial injury caused by the grain grown in those areas. |
| |
| Keywords: | Selenium Cadmium Myocardial diseases |
| 本文献已被 CNKI 维普 等数据库收录！ |
