| 氯酯醒清除羟自由基的体外实验研究 |
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| 引用本文： | 杨春水,陈俊宁.氯酯醒清除羟自由基的体外实验研究[J].南通医学院学报,1994,14(2):176-177. |
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| 作者姓名： | 杨春水 陈俊宁 |
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| 作者单位： | 上海第二医科大学，华东化工学院顺磁共振室 |
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| 摘 要： | 在体外通过Ｆｅｎｔｏｎ反应系统生成羟自由基（ＯＨ），用自由基捕捉剂ＤＭＰＯ捕捉生成的ＯＨ，形成保留ＯＨ性质的ＤＭＰＯ－ＯＨ自旋加合物，用电子自旋共振仪（ＥＳＲ）检测ＯＨ的生成量。研究发现，在Ｆｅｎｔｏｎ反应系统中加入不同浓度的氯酯醒，ＥＳＲ检测到的自旋加合物信号明显减弱。实验证实，氯酯醒具有羟自由基清除作用。
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| 关 键 词： | 氯酯醒 羟自由基 电子自旋共振 |
HYDROXYL FREE RADICAL SCAVENG ABILITY OF MECLOPHENOXATE IN VITRO |
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| Yang Chunshui, Chen Junning, Chen Tao, et al.HYDROXYL FREE RADICAL SCAVENG ABILITY OF MECLOPHENOXATE IN VITRO[J].ACTA Academiae Medicinae Nantong,1994,14(2):176-177. |
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| Authors: | Yang Chunshui Chen Junning Chen Tao |
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| Abstract: | The fenton reaction system generates OH'free radical which can be trapped by 5, 5-dimethy-1-pyrroline-N-oxide(MPO) thus yielding a measurable signal by clectron spin resonance(ESR) spectroscopy. We found that the signal of DMPO-OH'spin adduct detected using ESR remarkedly decreased when the meclophenoxate of different concentrations proved to be an OH'free radical scavenger in the fenton reaction system. On the basis of the experimental results, the OH'free radical scavenger property of meclophenoxate can be regarded as firmly established. |
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| Keywords: | meclophenoxate hydfoxyl free radical ESR |
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