食管鳞癌组织中基质金属蛋白酶-9、血管内皮生长因子的表达变化及意义

目的 观察食管鳞癌组织中基质金属蛋白酶-9（MMP-9）、血管内皮生长因子（VEGF）的表达变化及临床意义. 方法 采用免疫组织化学SP法检测60例食管鳞癌组织及20例癌旁正常黏膜的MMP-9、VEGF表达情况. 结果 MMP-9、VEGF表达阳性率：食管鳞癌组织中分别为70%（42/60）、80%（48/60）、癌旁正常黏膜为10%（2/20）、20%（4/20）,两者差异均有统计学意义（均P＜0.05）;食管鳞癌组织中MMP-9、VEGF表达均与癌组织浸润深度程度及有无淋巴结转移有关（均P＜0.05）,且两者的表达呈正相关（r=2.330,P＜0.05）. 结论 食管鳞癌组织中MMP-9、VEGF呈高表达,在食管鳞癌的侵袭转移中起重要作用.

The expression and clinical significance of MMP-9,VEGF in the esophageal squamous cell carcinomas

Objective To observe the expression changes of matrix metalloproteinase 9(MMP-9),vascular endothelial growth factor(VEGF)in the esophageal squamous cell carcinomas,and to study the chinical significance. Methods The expression of MMP-9 and VEGF in 60 patients with esophageal carcinoma and 20 cases with adjacent normal mucosa were tested with immunohistochemical SP method. Results The positive rate of MMP-9,VEGF in the esophageal squamous cell carcinomas were 70%(42/60)and 80%(48/60),the positive rate of adjacent normal mucosa were 10%(2/20)and 20%(4/20).The positive rates of the two groups were compared,all the differences had statistical significance(P＜0.05); expressions of MMP-9,VEGF in the esophageal squamous cell carcinomas related to invasive depth of carcinoma and lymph node metastasis(P＜0.05).There were positive correlation(r=2.330,P＜0.05). Conclusion The higher expression of MMP-9 and VEGF in the esophageal squamous cell carcinomas played an important role in invasion and metastasis of esophagus squamous cancer.