抵抗素与炎症、动脉粥样硬化研究进展

抵抗素最初被认为是联系肥胖与胰岛素抵抗、2型糖尿病的脂肪细胞因子。然而近年来研究发现其在人体主要与炎症有关，抵抗素不仅促进炎症的发生，而且炎症因子也可影响抵抗素的表达。动脉粥样硬化是一种慢性亚临床性炎症，大量的研究表明抵抗素与动脉粥样硬化相关。抵抗素通过局部和全身炎症作用诱导内皮功能失调、巨噬细胞的脂质沉积以及平滑肌增殖迁移，从而促进动脉粥样硬化的发生发展。

The development of studies on resistin and inflammation,atherosclerosis

As an adipocytokine, resistin was initially thought to be a link between obesity and insulin resistance, type 2 diabetes mellitus. However, recent researches found that resistin was mainly associated with inflammation in human. Atherosclerosis is a disease with low-grade inflammation. It has been shown recently that resistin plays a role in the development of atherosclerosis. Resistin could induce endothelial dysfunction, promote lipidoses in macrophages, and promote smooth muscle cells proliferation and mi...