Role of radiology in the diagnosis of neurosarcoidosis |
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Authors: | D Pickuth R P Spielmann S H Heywang-Köbrunner |
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Institution: | (1) Department of Diagnostic Radiology, Faculty of Medicine, Martin Luther University, Magdeburger Strasse 16, D-06112 Halle/Saale, Germany, DE |
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Abstract: | Clinical studies report a rate of 5 % and autopsy results a rate of 25 % of brain involvement in sarcoidosis. The aim of
this study was to evaluate the role of radiology in the diagnosis of patients with neurosarcoidosis. The chest radiographs
and MRI brain scans of 22 patients with sarcoidosis were retrospectively reviewed, along with the information that was provided
in the request form and clinical charts. All patients had neurological signs and symptoms; 21 patients were examined with
contrast enhancement. Facial nerve paralysis was the most common clinical manifestation identified in 10 patients. A wide
spectrum of MR findings was noted: periventricular high-signal lesions on T2-weighted images (46 %); multiple supratentorial
and infratentorial brain lesions (36 %); solitary intra-axial mass (9 %); solitary extra-axial mass (5 %); and leptomeningeal
enhancement (36 %). Neurological signs and symptoms can be significant manifestations of sarcoidosis. Magnetic resonance imaging
shows a wide spectrum of brain abnormalities associated with neurosarcoidosis. The patient's history and chest X-ray are helpful
in arriving at the correct diagnosis, but in selected cases with isolated brain involvement biopsy may still be required.
Received: 21 June 1999; Revised: 27 August 1999; Accepted: 15 October 1999 |
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Keywords: | : Neurosarcoidosis – Differential diagnosis – Chest X-ray – Magnetic resonance imaging |
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