艾普拉唑、阿莫西林、左氧氟沙星三联法治疗幽门螺杆菌感染的临床观察

目的探讨艾普拉唑+阿莫西林+左氧氟沙星1周疗法根除幽门螺杆菌(HP)的疗效及安全性。方法选择91例HP阳性消化性溃疡患者,随机分为2组。治疗组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+左氧氟沙星(200 mg,2次/d)联合治疗。对照组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+甲硝唑(400 mg,2次/d)联合治疗。两组治疗7 d后继续用艾普拉唑5 mg,1次/d,共3周。疗程结束4周后复查胃镜和HP,观察HP根除率、症状缓解率、溃疡愈合率和不良反应。结果治疗组和对照组的HP根除率分别为91.3%、73.3%(P<0.05),治疗组和对照组症状缓解率、溃疡愈合率和不良反应发生率分别为8.7%vs.6.7%、89.1%vs.84.4%、19.7%vs.17.8%,两组比较,差异均无统计学意义(P>0.05)。结论艾普拉唑+阿莫西林+左氧氟沙星三联1周疗法是根除HP的理想方案。

Clinical efficacy of triple therapy of ilaprazole,amoxicillin and levofloxacin on Helicobacter pylori eradication

Objective To discuss the efficacy and safety of triple therapy of ilaprazole,amoxicillin and levofloxacin on Helicobacter pylori(Hp)eradication.Methods 91 patients with Hp infection suffering from peptic ulcer were randomized to treatment group and control group.The treatment group were administered ilaprazole(5 mg,twice daily)+ amoxicillin(1 000 mg,twice daily)+ levofloxacin(200 mg,twice daily)for a week.The control group were administered ilaprazole(5 mg,twice daily)+ amoxicillin(1 000 mg,twice daily)+ metronidazole(400 mg,twice daily)for a week.All patients were treated with ilaprazole(5 mg,once daily)for another 3 weeks.The Hp eradication,symptoms,peptic ulcer healing and side-effects were observed after 4 weeks.Results The Hp eradication rate of treatment group and control group were 91.3 % and 73.3 % respectively(P<0.05).The symptom ameliorate rate,peptic ulcer healing rate and side-effect rate of treatment group and control group were 8.7 % vs.6.7%(P>0.05),89.1 % vs.84.4 %(P>0.05),19.7 % vs.17.8 %(P>0.05),respectively.Conclusion The triple therapy of ilaprazole,amoxicillin and levofloxacin(1 week)is ideal for Hp eradication.