调脂药物的联合应用及安全性监测

血脂异常是动脉粥样硬化性心脑血管疾病的重要危险因素。他汀类药物通过降低低密度脂蛋白胆固醇水平,使心血管事件明显减少。但是即使采用大剂量的他汀类药物仍难以达到指南要求的血脂水平标准,因此针对合并糖尿病、代谢综合征等心血管高危人群,他汀类药物联合贝特类、烟酸类、胆固醇吸收抑制药等药物成为临床上的重要选择。

Combination of Lipid-Lowering Drugs and the Safety Monitoring

Dyslipidemia is an important risk factor for atherosclerotic cardio-cerebro-vascular diseases.Clinical studies have shown that statins could significantly reduced cardiovascular events by reducing the level of low density lipoprotein cholesterol.However,it is difficult to achieve standard serum lipid levels recommended by guideline even with high doses of statins.For high-risk groups with diabetes or metabolic syndrome,the combination of statins and fibrates,niacin,cholesterol absorption inhibitors would be a preferable alternative in clinical.