山莨菪碱对妊娠高血压综合征子宫胎盘血流影响

目的：观察山莨菪碱对妊娠高血压综合征(妊高征)子宫动脉、脐动脉血流的短期影响.方法：妊高征患者14例给予山莨菪碱10～20 mg加入5%葡萄糖溶液500 mL中,静脉滴注,观察用药前后血压、体重、蛋白尿变化,多普勒超声监测用药前后子宫动脉、脐动脉的收缩期峰值(S)/舒张末期血流速度(D)(S/D),阻力指数(RI)、搏动指数(PI).结果：用药后收缩压及舒张压明显下降(P＜0.05)；水肿、蛋白尿减轻或消退；子宫动脉和脐动脉的S/D、RI、PI均明显下降(P＜0.01).结论：山莨菪碱治疗妊高征能降低子宫、胎盘血流阻力,增加其血流灌注,同时改善孕妇临床症状,有利于母婴预后.

Effect of Anisodamine on Uteroplacental Circulation in Pregnancy-induced Hypertension

Objective:To observe the short-term effect of anisodamine on blood flow of uterine and umbilical arteries in 14 pregnant women with pregnancy induced hypertension (PIH) by means of colour doppler. Method:14 cases of pregcancy induced hypertension were given anisodamine 10-20 mg added into 500 mL 5% GS by intravenous drip. We observed the blood pressure, weight and proteinuria before and after therapy and measured blood flow of uterine and umbilical arteries by means of doppler ultrasound technique. Results:Anisodamine could decrease the S/D ratio, resistant index(RI), and pulsative index(PI) of blood velocity in these arteries with statistically significant difference( P <0.01). Conclusion: The resistance in uteroplacental circulation was decreased and its perfusion improved, which favors the maternal and fetal growth and development.