Effect of Homoharringtonine on Bone Morrow CD34^+CD7^+ Cells in Chronic Granulocytic Leukemia |
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引用本文: | 李玉峰,邓之奎,宣衡报,陈宝安.Effect of Homoharringtonine on Bone Morrow CD34^+CD7^+ Cells in Chronic Granulocytic Leukemia[J].中国癌症研究,2007,19(2):141-145. |
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作者姓名: | 李玉峰 邓之奎 宣衡报 陈宝安 |
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作者单位: | [1]The First Hospital of Huaian, Nanjing Medical University, Huaian, 223300 [2]Medical College of Southeast University, Nanjing 210000 |
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摘 要: | Objective: To explore the effect of homoharringtonine (HHT) on bone morrow CD34^+CD7^+ cells in chronic granulocytic leukemia (CGL). Methods: The changes of bone morrow CD34^+CD7^+ cells were observed after the treatment of HHT in 23 cases with CGL. The proliferation and apoptosis of CD34^+CD7^+ cells treated with HHT in vitro were studied. Results: The proportion of CD34^+CD7^+ cells in CGL (0.145±0.021) was higher than that of normal control (0.052±0.013). The proportion of CD34^+CD7^+ cells in patients who got cytogenetic responses to HHT (0.072±0.020) decreased remarkably, but not in those patients who did not got cytogenetic responses to HHT, (0.137±0.023). the proliferation of CD34^+ cells was inhibited and the proportion of CD34^+CD7^+ cells decreased after cultured with HHT (0.134 in 24 h, 0.126 in 48 h and 0.102 in 72). The apoptosis rate of CD34^+CD7^+ cells was higher than that in CD34^+CDT cells (35.39%±4.39% versus 24.57%±4.01%, P〈0.05) 72 h after culture with HHT. Conclusion: The proportion of CD34^+CD7^+ cells in CGL was higher than that of normal control and HHT may inhibit the proliferation and induce apoptosis of bone marrow CD34^+CD7^+ cells.
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关 键 词: | 高三尖杉酯碱 治疗 慢性粒细胞性白血病 骨髓CD34^+CD7^+细胞 |
文章编号: | 1000-9604(2007)02-0141-05 |
收稿时间: | 23 January 2007 |
修稿时间: | 2007-01-232007-03-30 |
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