Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level |
| |
Authors: | Eriguchi N Aoyagi S Hara M Okuda K Saito N Fukuda S Akashi H Kutami R Jimi A |
| |
Affiliation: | (1) Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan, JP;(2) Department of Pathology, Kurume University School of Medicine, Kurume, Japan, JP |
| |
Abstract: | A pancreatic carcinoma, associated with elevated serum alpha-fetoprotein level, was resected from a 67-year-old man. The tumor was strongly suggested to be an acinar cell carcinoma of the pancreas, based on the histological findings of the resected specimen. The tumor measured 12 × 10 × 9 cm, and the cut surface was soft, whitish-yellow, focally necrotic, and hemorrhagic. Under a light microscope, the tumor cells were not arranged in a tubular and trabecular pattern, but rather, showed a tendency toward an acinar structure. Immunohistochemically, α 1-antitrypsin- and α 1-antichymotrypsin-positive reactions were diffusely positive in most of the tumor cells, while staining for chromogranin, neuron-specific enolase, Grimelius, glucagon, insulin, and alpha-fetoprotein was negative in the tumor cells. We report a large acinar cell carcinoma (associated with elevated serum alpha-fetoprotein level), which had been misdiagnosed as hepatocellular carcinoma preoperatively. Received for publication on May 9, 1998; accepted on Sept. 20, 1999 |
| |
Keywords: | : alpha-fetoprotein (AFP) pancreas acinar cell carcinoma |
本文献已被 PubMed SpringerLink 等数据库收录! |
|