香菇多糖辅助胃癌患者术后化疗的临床观察

目的 :探讨香菇多糖减轻胃癌患者术后化疗毒副反应的效果和对患者长期生存的影响。方法 :设计两组患者作为研究对象 ,对照组 (n =5 1)用 5 Fu、阿霉素、丝裂霉素方案 ;治疗组 (n =32 )用香菇多糖、5 Fu、阿霉素、丝裂霉素方案。毒副反应按WHO标准评估 ,长期生存及长期无瘤生存用寿命表法分析。结果 :治疗组比对照组在血液学 (P <0 0 1)、胃肠道 (P <0 0 1)、皮肤及毛发 (0 0 5 >P >0 0 1)上的毒副反应明显下降 ;且较对照组能耐受更多疗程化疗 (P <0 0 1) ;但在五年生存率及五年无瘤生存率上治疗组与对照组无显著性差异 (五年生存率分别是 4 6 88%和 4 5 10 % ,P >0 0 5 ,五年无瘤生存率相同 )。结论 :香菇多糖可减少胃癌患者术后化疗的毒副反应 ,但对长期生存无明显影响

The Clinical Observation of Lentinan Assisted Chemotherapy for the Patients with Resected Gastric Cancer

Objective:To investigate the effects of lentinan in decreasing the side effects of chemotherapy and influencing the long term survival of patients with resected gastric cancer.Methods:A protocol consisting of patients administered 5 Fu, ADM and MMC (control group, n=51), and patients administered lentinan, 5 Fu, ADM and MMC (test group, n=32) was performed. Side effects of chemotherapy (short term results) were evaluated by WHO standard. Long term survival and tumor free survival were analysed with survival table.Results:Side effects of chemotherapy in hematology ( P <0 01), gastroenterology ( P <0 01), skin and hair (0 05> P >0 01) were decreased in test group. Patients in test group could endure more courses of chemotherapy than in control group ( P <0 01). But the 5 year survival rate and 5year tumor free survival rate was not significantly improved in test group than in control group (survial rate:46 88% vs 45 10%, P >0 05; tumor free survival rate is the same).Conclusion:Lentinan is considered to decrease the side effect of chemotherapy, but not to influence the long term survival of patients with resected gastric cancer.