| 内蒙古地区蒙古族人群ACE基因多态性 |
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| 引用本文： | 陈阿梅,闫文瑛.内蒙古地区蒙古族人群ACE基因多态性[J].内蒙古医学院学报,1999,21(4):215-217. |
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| 作者姓名： | 陈阿梅 闫文瑛 |
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| 作者单位： | 内蒙古医学院组织胚胎学教研室(陈阿梅，崔明玉，戴云鹏，旭日)，内蒙古医学院(闫文瑛) |
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| 摘 要： | 目的：分析ＡＣＥ 基因第１６ 内含子Ｉ／Ｄ 在内蒙古地区蒙古族人群中分布的多态性。方法：ＤＮＡ 提取自９６ 名健康蒙古族，应用ＡＣＥ 基因内含子１６ 多态部位侧翼的前体进行ＰＣＲ 反应。等位基因在琼脂胶上电泳，紫外灯下观察。结果：蒙古族ＤＤ、ＤＩ和ＩＩ基因型的频率是０－５１、０－２６ 和０－２３ 。等位基因Ｄ 和Ｉ频率是０－６４ 和０－３６ 。结论：内蒙古地区蒙古族ＤＤ、ＤＩ和ＩＩ基因型频率和汉族人群之间有显著性差异。蒙古族人群中ＡＣＥ 等位基因和基因型的分布；Ｄ 等位基因比Ｉ等位基因频率高，ＤＤ 基因型是最普遍的。
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| 关 键 词： | 血管紧张素转化酶基因 插入缺失多态性 蒙古族 |
A STUDY OF INSERTION/DELETION POLYMORPHISM OF ACE GENE IN MONGOLIAN |
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| CHEN A mei,YAN Wen ying,CUI Ming yu et al.A STUDY OF INSERTION/DELETION POLYMORPHISM OF ACE GENE IN MONGOLIAN[J].Acta Academiae Medicinae Neimongol,1999,21(4):215-217. |
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| Authors: | CHEN A mei YAN Wen ying CUI Ming yu |
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| Abstract: | Objective:To analyse the insertion/deletion polymorphism of ACE gene in Mongolian.Methods:The fragment located at intron 16 of ACE gene were examined by PCR. Results:The frequencies of DD, DI and II genotype were 0.51, 0.26 and 0.23 in Mongolian.Allele frequencies for D and I were 0.64 and 0 36.Conclusion:The genotype of Mongolian were compared with the genotype of Hans, showing a significant difference between these two nationalities. The ACE allele and genotype frequencies are reported for Inner Mongolia Mongolian. The D allele occurs more frequently than I allele and DD genotype is the most common. |
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| Keywords: | ACE gene insertion/deletion polymorphism Mongolian |
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