Effects of MDMA on sociability and neural response to social threat and social reward |
| |
Authors: | Gillinder Bedi K Luan Phan Mike Angstadt and Harriet de Wit |
| |
Institution: | (1) Department of Psychiatry, Duke University Medical Center, Durham, NC, USA;(2) Duke ADHD Program, 718 Rutherford Street, Durham, NC 27701, USA |
| |
Abstract: | Rationale There has been controversy over the abuse potential of methylphenidate (MPH) in the context of treatment for attention deficit
hyperactivity disorder (ADHD).
Objective The objective of this study was to compare the reinforcing and subjective effects of oral MPH in adults with and without ADHD.
Materials and methods Following screening, 33 adults (n = 16 with ADHD; n = 17 free from psychiatric diagnoses) completed four pairs of experimental sessions, each of which included a sampling session
and a self-administration session. During sampling sessions, subjects received in randomized order 0 (placebo), 20, 40, and
60 mg MPH. During self-administration sessions, subjects completed a progressive ratio (PR) task to earn portions of the dose
received on the corresponding sampling session. Subjective effects were recorded throughout all sessions. The main outcome
measure for the study was the number of ratios completed on the PR task. Secondary measures included peak subjective effects
and area-under-the-curve values for subjective effects.
Results Compared to the control group, the ADHD group completed more ratios on the PR task. Both groups showed robust effects of methylphenidate
on subjective endpoints. Main effects of group were noted on subjective effects involving concentration and arousal.
Conclusions Compared to placebo, MPH produced reinforcing effects only for the ADHD group and not for the control group. Increases in
stimulant-related subjective effects in non-ADHD subjects were not associated with drug reinforcement.
|
| |
Keywords: | Methylphenidate Abuse potential Drug reinforcement ADHD Subjective effects |
本文献已被 SpringerLink 等数据库收录! |
|