| 醋酸奥曲肽的固相合成 |
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| 引用本文： | 刘作家,贾志丹,梁涌涛,王恩思. 醋酸奥曲肽的固相合成[J]. 中国药物化学杂志, 2004, 14(1): 33-35 |
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| 作者姓名： | 刘作家 贾志丹 梁涌涛 王恩思 |
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| 作者单位： | 1. 吉林大学生命科学学院,吉林,长春,130023
2. 吉林大学生命科学学院,吉林,长春,130023;吉林大学药学院,吉林,长春,130021 |
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| 摘 要： | 目的设计并合成醋酸奥曲肽.方法采用固相多肽合成法,使用逐步缩合的战略合成奥曲肽.结果与结论合成了醋酸奥曲肽,纯品总收率为30%(以连到树脂上的第一个氨基酸计).关键中间体及最终产物的结构经质谱、红外光谱、核磁共振氢谱及碳谱得到确证.
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| 关 键 词： | 药物化学 制备 固相肽合成 奥曲肽 生长抑素 环肽 |
| 文章编号： | 1005-0108(2004)01-0033-03 |
Solid-phase synthesis of octreotide acetate |
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| LIU Zuo-jia ,JIA Zhi-dan ,LIANG Yong-tao ,WANG En-si . Solid-phase synthesis of octreotide acetate[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(1): 33-35 |
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| Authors: | LIU Zuo-jia JIA Zhi-dan LIANG Yong-tao WANG En-si |
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| Affiliation: | LIU Zuo-jia 1,JIA Zhi-dan 1,LIANG Yong-tao 1,WANG En-si 1,2 |
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| Abstract: | Aim To design and synthesize octreotide acetate.Method Octreotide was synthesized by the solid-phase peptide synthesis method and stepwise condensation strategy.Result and conclusion Octreotide acetate was synthesized.The total yield was 30%(calculated from the first amino acid anchored to Resin).The structures of the key intermediates and target molecule were confirmed by ESI-MS,IR and NMR. |
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| Keywords: | medicinal chemistry preparation solid-phase peptide synthesis octreotide somatostatin cycle peptide |
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