55例慢性重型肝炎患者血清瘦素水平测定与肝脏功能的相关性研究

目的：通过测定慢性重型肝病患者血清瘦素水平，研究患者血清瘦素与PTCHO及肝脏功能之间相关关系。方法：选择55名慢性重型肝病患者的血清采用放射免疫方法测定血清瘦素，并测定凝血酶原时间（PT）、丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、总胆红素年龄（TBIL）、血清白蛋白（ALB）、总胆固醇（CHO）、胆汁酸（TBA）值。结果：对55名慢性重型肝炎患者的血清测定值与PT、AIT、AST、TBIL、ALB、CHO、TBA做多元统计回归分析，总胆红素年龄和总胆固醇对血清瘦素有显著的影响，采用多元相关性分析年龄和总胆固醇与血清瘦素有显著相关性。采用两变量相关分析血清瘦素与门冬氨酸氨基转移酶和凝血酶原时间有显著相关性。结论：血清瘦素水平与肝脏损伤坏死的严重程度有相关性，瘦素水平反映肝脏损伤坏死的程度。

A clinic correlation of serum leption with liver function of chronic sever hepatitis: a case clinic study

Objective: To determine serum leptin levels and study their correlations with CHO,PT and biochemical liver function in patients with chronic severe hepatitis.Methods: Fifty five chronic severe hepatitis patients were enrolled in this study.Serum leptin levels were determined by radioimmunoassay.The biochemical liver function ALT,AST,TBIL,ALB and PT were determined at the same time.The correlations of serum leptin levels with PT and biochemical liver function were assessed statistically.Results: Serum leptin concentrations wes determined by a radioimmunoassay in 55 patients with chronic sever hepatitis.Significant correlations were found between serum leptin and total cholesterol(P=-0.396,P<0.05).Serum leptin and age TBIL,TBA,AST were significantly correlated.A linear logistic regression analysis was performed with serum leptin levels as dependent variable and age,TBIL,TBA,AST,ALB,ALT as independent variables in chronic severe hepatitis.The correlations of serum leptin levels with PT and biochemical liver function were assessed statistically by bivariate.Conclusions: Leptin levels were associated with severity of impaired hepatic function in patients with chronic severe hepatitis.Leptin participated injury and necrosis of hepatocyte.