Cutaneous lesions of Kikuchi's disease: Evolution of histopathological findings |
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| Authors: | Kyoko Kanno Masako Minami‐Hori Akemi Ishida‐Yamamoto Keiji Komura Kensuke Oikawa Naoyuki Miyokawa Hajime Iizuka |
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| Affiliation: | 1. Department of Dermatology, Asahikawa Medical University, , Asahikawa, Japan;2. Department of Internal Medicine, Asahikawa Medical University, , Asahikawa, Japan;3. Department of Pathology, Asahikawa Medical University, , Asahikawa, Japan |
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| Abstract: | We report a 38‐year‐old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high‐grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68‐positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. The histopathology of skin lesions of KD may vary during the clinical course, which may reflect the stage of the disease. |
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| Keywords: | apoptotic keratinocytes CD68 Kikuchi's disease nuclear debris systemic lupus erythematosus |
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