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Rapid determination of platinum by flameless atomic absorption spectrophotometry following the administration of cisplatin to cancer patients
Authors:A el-Yazigi  I Al-Saleh
Abstract:An improved flameless atomic absorption spectrophotometric method for the analysis of platinum in plasma is described. Following a simple dilution with Triton X-100, the sample is directly injected into the graphite furnace with a total analysis time of less than 2 min. The assay is precise (CV less than 4.3%) and linear (r greater than 0.9922) in the ranges 0.05-1 and 1-4 mg/L for cisplatin. The applicability of the method is examined by analyzing samples obtained at different intervals from two patients treated with cisplatin.
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