Different neuronal location of [3H]SCH 23390 binding sites in pars reticulata and pars compacta of the substantia nigra in the rat期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Different neuronal location of [3H]SCH 23390 binding sites in pars reticulata and pars compacta of the substantia nigra in the rat

Authors:	M Savasta A Dubois J Benavides B Scatton

Affiliation:	1. Respiratory Medicine Department, CHU Rennes, Rennes, France;2. CLCC Eugène Marquis, Service d’oncologie médicale, Rennes, France;3. Neurology Department, CHU Rennes, Rennes, France;4. Respiratory Medicine Department, CH Saint-Malo, Saint-Malo, France;5. INSERM U1242, Chemistry Oncogenesis Stress and Signaling, CLCC Eugène Marquis, Rennes, France;1. Department of Neurology, 4500 San Pablo Road, Jacksonville, FL 32224, USA;2. Department of Neuropathology, 4500 San Pablo Road, Jacksonville, FL 32224, USA;3. Department of Neuroscience Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA;4. Department of Neurology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Fukuoka 814-0180, Japan;1. Institute for Innovative Learning, Mahidol University, Nakhon Pathom 73170, Thailand;2. Department of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand;3. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand;1. Department of Clinical Pharmacology, Paul Sabatier University and Toulouse University Hospital, Toulouse, France;2. INSERM UMR825 Neuroimaging and Neurologic Diseases, Toulouse, France;3. Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Switzerland;4. LN-Pharma, Toulouse, France;5. Sleep Medicine and Epilepsy Unit, IRCCS “C. Mondino National Institute of Neurology” Foundation, Pavia, Italy;6. Pôle Neurosciences, Centre Hospitalier Universitaire de Nantes, Centre d’Investigation Clinique CIC 04, Nantes, France;7. Service de Neurologie, Groupe Hospitalier Sud, Hôpital Haut-Lévèque, Centre Hospitalier Universitaire de Bordeaux, France;8. Service de Neurologie et pathologie du mouvement, Pôle de Neurologie, Centre Hospitalier Universitaire de Lille, France;9. Centre d’Investigation Clinique CIC 9302, Toulouse University Hospital, Toulouse, France;1. Department of Pathology, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, 02115 USA;2. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215 USA;3. Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215 USA

Abstract:	The precise neuronal localization of D1 receptors in the substantia nigra has been studied autoradiographically in the rat by measuring the alterations of [3H]SCH 23390 binding site densities in this brain area after 6-hydroxydopamine (6-OHDA) induced destruction of nigrostriatal dopaminergic neurons and after ibotenate-induced lesion of striatal afferents. 6-OHDA-induced nigral lesion provoked a total loss of [3H]SCH 23390 binding sites in the pars compacta and pars lateralis (but not in the pars reticulata) of the substantia nigra. In contrast, ibotenate-induced striatal lesion caused a large diminution of the [3H]ligand binding site density in the pars reticulata but not in the pars compacta and pars lateralis of the substantia nigra. These results suggest that D1 receptors in the pars compacta or pars lateralis of the substantia nigra are located on the dopaminergic perikarya whereas those D1 receptors present in the pars reticulata of the substantia nigra lie on the terminals of nigral afferents of striatal origin.

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