| E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义 |
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| 引用本文： | 郑彩云,汪鹏,沈显军,王舒仪,郑海红,施更生.E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义[J].医学研究杂志,2016,45(5):115-119. |
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| 作者姓名： | 郑彩云 汪鹏 沈显军 王舒仪 郑海红 施更生 |
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| 作者单位： | 317000 温州医科大学附属台州医院口腔科;317000 温州医科大学附属台州医院口腔科;317000 温州医科大学附属台州医院口腔科;317000 温州医科大学附属台州医院口腔科;317000 温州医科大学附属台州医院 病理科;317000 温州医科大学附属台州医院口腔科 |
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| 基金项目： | 台州市医学会研究基金资助项目(TZSYXH15-13) |
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| 摘 要： | 目的 研究E-cadherin和Slug在口腔鳞状细胞癌(OSCC)组织中的表达及临床意义。方法 采用免疫组织化学DAB显色法检测74例OSCC组织切片和30例正常口腔黏膜组织切片中E-cadherin和Slug的表达,分析E-cadherin与Slug在OSCC和正常口腔黏膜组织中的表达及E-cadherin与Slug的异常表达与临床病理特征之间的关系。结果 在OSCC组织中E-cadherin和Slug的阳性表达率分别为52.63%(40/74)和48.65%(36/74)。结合OSCC临床病理特征发现,E-cadherin的表达与肿瘤病理分级、淋巴结转移有统计学意义(P<0.05),Slug的表达与肿瘤病理分级、TNM分期、淋巴结转移有统计学意义(P<0.05),同时发现OSCC组织中E-cadherin的表达与Slug的表达呈负相关(r=-0.513,P<0.05)。结论 E-cadherin和Slug的表达异常可能与OSCC的发生、发展、转移相关,其二者的联合检测可作为判断OSCC恶性程度和预后的参考指标。
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| 关 键 词： | E-cadherin Slug EMT 口腔鳞状细胞癌 免疫组织化学 |
| 收稿时间： | 2015/9/25 0:00:00 |
| 修稿时间： | 2015/11/17 0:00:00 |
Expression and Clinical Significance of E-cadherin and Slug in Oral Squamous Cell Carcinoma |
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| Zheng Caiyun,Wang Peng,Shen Xianjun.Expression and Clinical Significance of E-cadherin and Slug in Oral Squamous Cell Carcinoma[J].Journal of Medical Research,2016,45(5):115-119. |
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| Authors: | Zheng Caiyun Wang Peng Shen Xianjun |
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| Institution: | Department of Stomatology, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang 317000, China;Department of Stomatology, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang 317000, China;Department of Stomatology, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang 317000, China;Department of Stomatology, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang 317000, China;Department of Stomatology, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang 317000, China |
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| Abstract: | Objective To explore the expression and the prognostic significance of E-cadherin and Slug in oral squamous cell carcinoma(OSCC)tissues. Methods We analyzed the E-cadherin,Slug expression in 74 patients with OSCC and 30 normal oral tissue by means of immunohistochemistry. Results E-cadherin,slug positive expression rate in OSCC was 52.63(40/74) and 48.65%(36/74).The results of clinical and pathological characteristics in OSCC showed that the expression of E-cadherin were associated with pathological and lymph node metastasis(P<0.05),while the the expression of Slug were associated with pathological,TNM stage and lymph node metastasis(P<0.05).The results also suggested that the expression of E-cadhein and Slug had a negative correlation(r=-0.513,P<0.05). Conclusion Expression of E-cadherin and Slug may correlate with occurrence,development and metastasis of OSCC.The expression of E-cadherin and Slug can be regarded as valuable indicators for evaluating biological behavior and the prognosis of OSCC. |
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| Keywords: | E-cadherin Slug EMT Oral squamous cell carcinoma Immunohistochemisty |
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