Novel mutations in the <Emphasis Type="Italic">BRCA1</Emphasis> and <Emphasis Type="Italic">BRCA2</Emphasis>genes in Iranian women with early-onset breast cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Novel mutations in the BRCA1 and BRCA2genes in Iranian women with early-onset breast cancer

Authors:	Vahid?R?Yassaee,Sirous?Zeinali,Iraj?Harirchi,Soghra?Jarvandi,Mohammad?A?Mohagheghi,David?P?Hornby,Ann?Dalton author-information" > author-information__contact u-icon-before" > mailto:ann.dalton@sch.nhs.uk" title=" ann.dalton@sch.nhs.uk" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, UK;(2) North Trent Molecular Genetics Laboratory, Sheffield Children's Hospital, Sheffield, UK;(3) Department of Molecular Biotechnology, Pasteur Institute, Tehran, Iran;(4) Iranian Centre for Breast Cancer (ICBC), Tehran University of Medical Sciences, Tehran, Iran;(5) Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;

Abstract:	Background Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified within the Iranian population.

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