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妊娠期糖尿病患者胎盘组织中miRNA-508-3p和HGF表达水平及其对滋养细胞胰岛素抵抗的影响
引用本文:黄好,贾虹,王晓霜,张鹭,段亚亭.妊娠期糖尿病患者胎盘组织中miRNA-508-3p和HGF表达水平及其对滋养细胞胰岛素抵抗的影响[J].吉林大学学报(医学版),2021,47(1):187-195.
作者姓名:黄好  贾虹  王晓霜  张鹭  段亚亭
作者单位:重庆市中医院妇产科,重庆 400011
重庆市中医院超声科,重庆 400011
基金项目:国家中医药管理局全国名老中医药专家传承工作室建设项目
摘    要:目的:探讨妊娠期糖尿病(GDM)患者胎盘组织中微小RNA-508-3p(miR-508-3p)与肝细胞生长因子(HGF)的表达及两者的相互作用,初步阐明miR-508-3p介导滋养细胞胰岛素抵抗(IR)的相关分子机制.方法:选取GDM患者及正常妊娠孕产妇各15例,分别为GDM组和正常对照组.采用实时定量PCR(RT-P...

关 键 词:妊娠期糖尿病  微小RNA-508-3p  肝细胞生长因子  胰岛素抵抗  滋养细胞
收稿时间:2020-04-27

Expressions of mi RNA-508-3p and HGF in placenta tissue of patients with gestational diabetes mellitus and their effects on trophoblast insulin resistance
HUANG Hao,JIA Hong,WANG Xiaoshuang,ZHANG Lu,DUAN Yating.Expressions of mi RNA-508-3p and HGF in placenta tissue of patients with gestational diabetes mellitus and their effects on trophoblast insulin resistance[J].Journal of Jilin University: Med Ed,2021,47(1):187-195.
Authors:HUANG Hao  JIA Hong  WANG Xiaoshuang  ZHANG Lu  DUAN Yating
Institution:Department of Gynecology and Obstetrics,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400011,China
Department of Ultrasound,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400011,China
Abstract:ObjectiveTo investigate the expressions of microRNA-508-3p (miR-508-3p) and hepatocyte growth factor (HGF) in placenta tissue of the patients with gestational diabetes mellitus (GDM) and their relationship, and to clarify the related molecular mechanism of miR-508-3p in mediating trophoblast insulin resistance(IR).
Keywords:gestational diabetes mellitus  microRNA-508-3p  hepatocyte growth factor  insulin resistance  trophoblasts  
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