2000-2016 年中国儿童孤独症谱系障碍患病率Meta分析

目的 运用Meta分析方法了解我国儿童孤独症谱系障碍(ASD)的流行现状。方法 检索2000-2016年在中国期刊全文数据库(CNKI)、万方数据资源系统(Wanfang data)、维普数据库(VIP)及PubMed中收录的有关中国儿童ASD患病率研究的文献。采用STATA 12.0软件进行数据合并估算患病率,并对性别和城乡因素进行亚组分析。结果 共纳入21篇文献,样本量215 700人,患病人数462人,合并患病率为0.24%(95%CI:0.18～0.29)。根据不同性别、城乡进行亚组分析,男性患病率0.35%(95%CI:0.26～0.44),女性患病率为0.07%(95%CI:0.05～0.10),差异有统计学意义(χ² =116.303,P＜0.001)。城市患病率0.17%(95%CI:0.08～0.26),乡村患病率0.09%(95%CI:0.05～0.12),差异无统计学意义(χ²=1.686,P=0.200 4)。结论 儿童ASD呈逐年上升趋势,应建立统一、规范的ASD患病率调查研究方法来进行ASD的流行病学研究,为加大对儿童ASD防治及进一步研究提供基础资料和参考。

Prevalence of autism spectrum disorder in Chinese children from 2010 to 2016:a meta-analysis

Objective To estimate the prevalence of autism spectrum disorder in China. Methods Studies from CNKI,Wanfang data,VIP and PubMed databases on related prevalence of ASD in Chinese between 2000 and 2016 were searched.Data were collected to estimate the prevalence by STATA 12.0 software.Subgroups analysis were conducted by gender and residence that may affect the prevalence of autism spectrum disorder. Results A total of 21 studies were included in this study.The total number of participants investigated was 215 700,including 462 patients.The estimated pooled prevalence of ASD was 0.24%(95%CI:0.18～0.29).The prevalence of ASD in male 0.35%(95%CI:0.26~0.44)] was significantly higher than that in female 0.07%(95%CI:0.05~0.10)](χ² =116.303,P＜0.001).There was no significant difference between the prevalence of urban (0.17%,95%CI:0.08~0.26) and rural areas (0.09%,95%CI:0.05~0.12)(χ²=1.686,P=0.200 4). Conclusion Prevalence of ASD in Chinese children shows a general trend.It is suggested that high-quality survey should be conducted to provide basic information and strong evidence for ASD prevention,treatment and further research in other aspects.