反复呼吸道感染的运动障碍患儿免疫功能相关因素的研究

目的 探讨反复呼吸道感染(RRI)的运动障碍患儿免疫功能的相关因素,为降低运动障碍患儿康复期间RRI的发病率,更好地促进运动障碍患儿的综合康复。方法 收集郑州儿童医院康复医学科收治的80例运动障碍患儿临床资料,其中40例康复治疗期间RRI的患儿为RRI 组,40例为同期进行康复治疗的运动障碍患儿为对照组,将两组分别进行维生素A、25-(OH)D₃、无机元素(铁、锌、钙、铜、镁、铅)、免疫球蛋白(IgA、IgM、IgG)测定。结果 RRI患儿其体内维生素A(0.92±0.38 vs 1.24±0.35)、25-(OH)D₃(24.7±5.2 vs 28.1±6.8)、锌(28.96±6.06 vs 44.68±8.70)、铁(7.09±0.87 vs 8.25±1.14)、钙(1.31±0.12 vs 1.83±0.26)含量都明显低于对照组患儿;RRI患儿血清 IgA(0.48±0.11 vs 1.32±0.25)、IgM(0.88±0.19 vs 1.51±0.32)显著低于对照组,IgG水平与对照组比较差异无统计学意义。结论 运动障碍患儿康复治疗期间出现RRI,可能与维生素AD、锌、铁、钙的缺乏、体液免疫低下有关,定期加强相关因素的监测,适当给予相关因素异常的处理,能增强运动障碍患儿机体的抵抗力,降低RRI的发病率,缩短康复疗程,提高康复疗效。

Research of immune function related factors of children movement disorders with repeated respiratory infection

Objective To explore the related factors of immune function in movement disorder children with recurrent respiratory tract infection,and promote the comprehensive rehabilitation of children with movement disorders. Methods The clinical data of 80 patients with movement disorders were collected from the Department of Rehabilitation Medicine in Zhengzhou Children's Hospital,40 cases of recurrent respiratory tract infection during the rehabilitation treatment in group RRI,40 cases of children with movement disorders rehabilitation treatment for the same period as the control group,vitamin A,25-(OH)D₃,inorganic elements (iron,zinc,calcium,copper,magnesium,lead),immunoglobulin (IgA,IgM,IgG) were determined in two groups. Results Vitamin A (0.92±0.38 vs 1.24±0.35),25-(OH)D₃(24.7±5.2 vs 28.1±6.8),zinc (28.96±6.06 vs 44.68±8.70),iron (7.09±0.87 vs 8.25±1.14),calcium (1.31±1.83±0.12 vs 0.26) in RRI were significantly lower than those in the control group;The serum IgA (0.48±0.11 vs 1.32±0.25),IgM (0.88±0.19 vs 1.51±0.32) in RRI were significantly lower than those in the control group,no difference of IgG levels. Conclusions During the rehabilitation treatment of movement disorders children with recurrent respiratory tract infection,vitamin A,D,zinc,iron,calcium deficiency,low humoral immunity are related.To strengthen the monitoring of relevant factors regularly to give appropriate treatment and relative factors of abnormal,can enhance the body's resistance of movement disorder patients,reduce the incidence of recurrent respiratory tract infection rate and shorten the treatment course,and improve the curative effect of rehabilitation.