乳腺癌患者外周血循环内皮细胞动态变化和化疗效果的临床观察

目的 探讨动态监测循环内皮细胞（CEC）计数与乳腺癌患者化疗效果的关系。方法 收集2013年5月至2015年5月收治的42例乳腺癌患者的病例资料。流式细胞术检测患者外周血CEC数量，分析CEC计数与乳腺癌临床病理特征以及化疗效果的关系。结果42例乳腺癌患者外周血CEC计数为（339.26±184）个， 20例健康志愿者CEC计数为（85.95±60.47）个，差异有统计学意义（P<0.05）。CEC计数与TNM分期有关，与年龄、ER、PR以及HER-2等无关。化疗2个周期后CEC计数升高组的有效率（RR）为31.6%， CEC计数降低组为78.4%，差异有统计学意义（P<0.05）。化疗4个周期后CEC计数升高组的RR为46.2%，CEC计数降低组为87.0%，差异有统计学意义（P<0.05）。结论乳腺癌患者外周血CEC计数较健康志愿者显著升高，化疗后CEC计数的动态变化与化疗的客观反应率有关。

Clinical abservation on the dynamic changes of circulating endothelial cells in peripheral blood of breast cancer patients with chemotherapy efficacy

Objective To investigate the relationship between dynamic monitoring of circulating endothelial cell （CEC） count and chemotherapy efficacy in breast cancer patients. Methods Clinical data of 42 breast cancer patients from May 2013 to May 2015 were collected. The number of CEC in peripheral blood of patients was detected by flow cytometry. The relationship between CEC count and clinicopathological features of breast cancer and the chemotherapy efficacy was analyzed. Results The number of CEC in peripheral blood of 42 breast cancer patients was 339.26±184， and the CEC in 20 healthy volunteers was 85.95±60.47， the difference was statistically significant （P<0.05）. The number of CEC was associated with TNM staging， not associated with age，ER，PR and HER-2. After 2 cycles of chemotherapy， the response rate （RR） in CEC increasing group was 31.6%， and RR of CEC reducing group was 78.4%（P<0.05）. After 4 cycles of chemotherapy， the RR in CEC increasing group was 46.2%，lower than 87.0% of CEC reducing group， and the difference was statistically significant（P<0.05）. Conclusion The dynamic changes of CEC in breast cancer patients receiving chemotherapy was associated with the RR of chemotherapy.