软骨生长板相关因素调控生长的研究进展

软骨生长板(CGP)主要由软骨细胞及细胞外基质(ECM)构成。软骨细胞的增殖、分化、肥大及ECM的形成,是骨骼发育、线性生长的关键。因此,与CGP相关、调控生长的因素主要涉及作用于软骨细胞的生长激素-胰岛素样生长因子-1(GH-IGF-1)轴、多种激素、旁分泌因子、炎性细胞因子等及软骨ECM中的胶原蛋白、非胶原糖蛋白、蛋白聚糖等成分。既往对调控生长的研究主要集中在GH-IGF-1轴上,但近年来,GH-IGF-1轴之外、CGP上可调控生长的其他相关因素备受关注。

Research progress on growth regulation of cartilage growth plate

Cartilage growth plate (CGP) is mainly composed of chondrocytes and extracellular matrix (ECM).The proliferation,differentiation,hypertrophy of chondrocytes,and the formation of ECM,are the key to the development of bone and linear growth.Therefore,the factors related to CGP that regulation growth mainly include growth hormone-like insulin-like growth factor-1 (GH-IGF-1) axis,various hormones,paracrine factors and inflammatory cytokines acting on chondrocytes and collagen in cartilage ECM,non-collagen glycoprotein,proteoglycan and other ingredients.Previous studies mostly focused on the regulation of GH-IGF-1 axis growth,but other relevant factors on CGP beyond GH-IGF-1 axis that can control the growth receives more concern in recent years.