新生儿常见疾病早期血浆D-二聚体的检测及意义

目的 分析新生儿常见疾病中早期血浆D-二聚体的水平并探讨其临床意义。方法 常见新生儿疾病300例(实验组),健康新生儿50例(对照组),采集静脉血并检测D-二聚体含量。结果 新生儿轻度窒息组D-二聚体的水平(1 167.5±683.7)及重度窒息组D-二聚体的水平(5 399.5±3 123.3)与健康对照组(320.4±145.5)相比均明显升高,其中重度窒息组D-二聚体水平升高更加显著。新生儿感染性肺炎组D-二聚体的水平(2 406.8±1 559.5)与显著高于健康对照组(320.4±145.5),差异有统计学意义。新生儿呼吸窘迫综合征(NRDS)组D-二聚体的水平( 1 975.6±1 205.6)与健康对照组(320.4±145.5)相比明显升高。新生儿病理性黄疸组(401.1±229.1)与对照组(320.4±145.5)相比差异具有统计学意义,新生儿湿肺D-二聚体的水平(316.9±174.2)与对照组(320.4±145.5)相比差异无统计学意义。结论 血浆D-二聚体的检测对新生儿可能发生高凝状态和血栓性疾病的诊断及预后判断有一定实用价值。

Detection and significance of plasma D-dimer in early neonatal common diseases

Objective To investigate the clinical significance of plasma D-dimer level in early neonatal common diseases. Methods Venous blood samples were collected from 300 cases of neonatal common diseases (experimental group) and 50 cases of healthy newborns (control group).The level of D-dimer was tested by ELISA. Results Compare with the healthy control group (320.4±145.5),D-dimer levels of mild (1 167.5±683.7) and severe (5 399.5±3 123.3) neonatal asphyxia groups were both significantly increased,especially in severe neonatal asphyxia group.Compared with healthy control group (320.4±145.5),the D-dimer levels of neonatal pneumonia group (2 406.8±1 559.5) significantly increased.The D-dimer levels of neonatal respiratory distress syndrome (NRDS) group (1 975.6±1 205.66) and neonatal jaundice group (401.13±229.15) significantly increased compared with healthy control group (320.44±145.58),while neonatal wet lung disease group (316.92±174.29) had no statistically significant difference. Conclusion The plasma D-dimer testing has some practical value for diagnosis and prognosis of newborns hypercoagulable state and thrombotic disease.