内镜下逆行胰胆管造影术后胰腺炎的非药物预防研究进展

内镜下逆行胰胆管造影术(ERCP)已成为目前消化系统疾病的重要临床诊断及治疗手段,但其术后胰腺炎(post-ERCP pancreatitis,PEP)等并发症的高发病率大大限制了临床应用,亦给患者生命带来了严重威胁。预防PEP成为ERCP相关研究的热点。药物预防PEP的现状不容乐观,目前尚无一种药物可有效预防PEP;然而,非药物措施,如胰管支架植入术、导丝引导插管等在PEP的预防中显示出良好的效果,为PEP的有效预防带来了新希望。本文就非药物预防措施预防PEP的研究现状作一综述。

Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

ERCP has become an important method for diagnosis and treatment of digestive diseases,but the high incidences of post-ERCP complications(PEP),especially for post-ERCP pancreatitis,have limited its application.Prevention of PEP has become a focus of ERCP-related studies.Current drug prevention of PEP is not satisfactory,and there has not been a single drug which can effectively prevent PEP.In contrast,non-pharmacologic preventive techniques such as pancreatic stent placing and guide wire cannulation have bee...