Structure-activity relationships of dengue antiviral polycyclic quinones |
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Authors: | Laurent Dominique Baumann Francine Benoit Anne Gaelle Mortelecqe Alain Nitatpattana Narong Desvignes Isabelle Debitus Cécile Laille Manola Gonzalez Jean-Paul Chungue Eliane |
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Institution: | Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD - Université Paul Sabatier, Centre IRD, Nouméa, Nouvelle-Calédonie, France. |
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Abstract: | The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation. |
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