Does treatment with testosterone undecanoate improve the in-vitro fertilizing capacity of spermatozoa inpatients with idiopathic testicular failure?(results of a double blind study) |
| |
| Authors: | Comhaire F; Schoonjans F; Abdelmassih R; Gordts S; Campo R; Dhont M; Milingoss S; Gerris J |
| |
| Institution: | 1University Hospital, Department of Internal Medicine, Section Endocrinology Ghent,Belgium
2Clinica de Andrologia e Reproducoa Humana San Paulo, Brazil
3Leuven Institute for Fertility and Embryology Leuven
4University Hospital,Department of Obstetrics and Gynecology Ghent, Belgium
5Alexandra Maternity Hospital Athens, Greece
6Middelheim Hospital, Fertility Clinic Antwerp,Belgium |
| |
| Abstract: | Seventy-seven couples in whom conventional in-vitro fertilization(IVF)had remained unsuccessful because of low fertilization rateand abnormal sperm characteristics were given either testosteroneundecanoate 120 mg/day, or placebo during 3 months, after whicha new IVF treatment was applied under identical technical conditions.There were no significant changes in sperm characteristics amongthe treated and placebo couples and the fertilization rate showeda similar increase after treatment in both groups. No significantdifference in pregnancies occurred, with 32% pregnancies inthe placebo controls and 17%among couples treated with testosteroneundecanoate. It is concluded that testosterone undecanoate intakedoes not improve sperm characteristics, or the in-vitro fertilizingpotential, or pregnancy rate over those observed in the placebocontrols in cases with primary idiopathic testicular failure. |
| |
| Keywords: | Andriol/assisted reproduction/in-vitro fertilization/male infertility |
| 本文献已被 Oxford 等数据库收录！ |
|
