Anti-rat CD45RA monoclonal antibodies cross-react with glucagon |
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| Authors: | Kaino Y Ito T Hirai H Kida K |
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| Institution: | Department of Pediatrics, Ehime University School of Medicine, Shigenobu, Japan. kaino@m.ehime-u.ac.jp |
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| Abstract: | Anti-rat CD45RA monoclonal antibody (MAb) has been used as a marker for rat B-lymphocytes (B-cells). When we applied the MAb to identify B-lymphocytes among immune cells infiltrating pancreatic islets of the BB rat, which is an animal model for human type 1 diabetes mellitus, a subpopulation of islet cells was immunostained as well. Our immunohistochemical investigations demonstrated that the stained islet cells are pancreatic alpha-cells and the MAb cross-reacts with glucagon. |
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| Keywords: | anti-rat CD45RA antibody MRC OX-33 B-lymphocyte glucagon cross-reactivity BB rat type 1 diabetes mellitus |
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