头孢哌酮/舒巴坦与头孢噻肟随机对照及开放治疗细菌性感染60例临床评价

目的 :评价国产头孢哌酮 /舒巴坦治疗细菌性感染的有效性和安全性。方法 :60例感染患者被选入随机对照及开放试验。结果 :随机对照组 4 3例 ,两组痊愈率和有效率分别为 77 2 7% ,71 4 3 %和 95 5 1% ,90 5 %。细菌阳性率为 95 4 5 %和95 2 4 %。细菌清除率为 90 4 8%和 90 0 %。不良反应发生率为 9 0 9%和 9 5 2 %。以上结果经统计学处理均无显著差异 (P>0 0 5 )。开放试验组 17例 ,其痊愈率和有效率分别为 73 3 3 %和 93 3 3 %。细菌阳性率为 94 1%。细菌清除率为 87 5 %。不良反应发生率为 12 0 %。全部临床分离菌株纸片法药敏试验及MIC结果表明头孢哌酮 /舒巴坦明显优于氨苄青霉素 /克拉维酸。结论 :头孢哌酮 /舒巴坦可作为临床上常见致病菌所致中至重度感染的选择用药。

A randomized controlled clinical trial of cefoperazone/sulbactam

OBJECTIVE :Toevaluatetheefficacyandsafetyofcefoperazone/sulbactaminthetreatmentofbacterial infections METHODS :60patientswithinfectionwereenrolledinarandomizedcontrolledopenclinicaltrial RESULTS :Intheran domizedcontrolledgroup ,theoverallclinicalefficacyratesofcefoperazone/sulbactamandcefotaximewere 95 5 1%and 90 5 %re spectively,thebacteriologicalresponsewere 95 2 3 %and 90 0 %respectively ,theratesofadversedrugreactionwere 9 0 9%and 9 5 2 %respectively Therewasnosignificantdifferencebetweenthetwogroups Intheopengroup ,theclinicalefficacyrate ,thebac teriologicaleradicationandtherateofadversedrugreactionofcefoperazone/sulbactamwas 95 3 3 % ,87,5 %and 12 0 %respective ly Thesusceptibilityratesofthebacteriaisolatedtocefoperazone/sulbactamandcefotaximeweresimilar CONCLUSIONS :cefopera zone/sulbactamishighlyeffectiveandwelltolerated