事故倾向性驾驶员血清BDNF水平和相关因素分析

目的 探讨事故倾向性驾驶员发生事故的相关因素及其脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）水平与事故倾向性驾驶员是否存在关联。方法 采用病例对照的方法，各收集50例事故倾向性驾驶员和安全驾驶员的一般情况及生活习惯，并采用酶联免疫吸附试验（enzyme linked immunosorbent assay，ELISA）测定所有研究对象的血清BDNF水平。结果 病例组血清BDNF水平（3.18±2.19）ng/ml高于对照组水平（2.23±1.43）ng/ml,差异有统计学意义（t=-2.564，P=0.012）；病例组驾龄<10年的驾驶员血清BDNF水平高于对照组，差异有统计学意义（t=-2.141，P=0.038）；病例组初中及以下的驾驶员血清BDNF水平高于对照组，差异有统计学意义（t=-2.562，P=0.018）；病例组其他民族的驾驶员血清BDNF水平高于对照组，差异有统计学意义（t=-3.047，P=0.004）；非条件Logistic回归结果显示出生地和锻炼频率为事故倾向性的相关因素（均有P<0.05）。结论 血清BDNF水平与事故倾向性驾驶员发生事故有关联，出生在乡镇、城市和高锻炼频率可能为事故倾向性保护因素。

An analysis of serum levels of BDNF and relative factors in the accident tendentiousness of drivers

Objective To explore the related factors of the accident tendentiousness drivers, and to investigate the relationship between the serum levels of brain-derived neurotrophic factor (BDNF) and the accident tendentiousness drivers. Methods A case-control study, including 50 patients and 50 controls, were inquired the general condition and the living habits by questionnaire, and serum BDNF levels were assayed by enzyme linked immunosorbent assay (ELISA). Results Serum BDNF was significantly higher (t=-2.564,P=0.012) in patients (3.18±2.19)ng/ml] compared with the controls (2.23±1.43)ng/ml]. Serum BDNF levels of the drivers with driving experience <10 years in exposure group was significantly higher(t=-2.141,P=0.038) than those in control group. Serum BDNF levels of the drivers with primary school and junior middle school education in exposure group was significantly higher(t=-2.562,P=0.018) than those in control group. Serum BDNF levels of the drivers with ethnic minorities in exposure group was significantly higher(t=-3.047,P=0.004) compared with the control group. Non-conditional logistic regression analyses showed that the relative factors of the accident proneness were birth place and exercise frequency(all P<0.05). Conclusions Our results suggest that the driver accident tendentiousness are associated with serum BDNF levels, and birth place and exercise frequency may be protective factors of the accident proneness.