深圳市已婚妊娠梅毒患者配偶的梅毒感染情况及影响因素分析

目的 了解已婚妊娠梅毒患者配偶的梅毒感染情况，并从妊娠梅毒患者及配偶自身角度分析影响配偶感染梅毒的因素。方法 对2008-2011年间在深圳市确诊感染梅毒的已婚孕产妇进行调查和配偶追踪，并对就诊的配偶进行甲苯胺红不加热血清试验（tolulized red unheated serum test，TRUST）和梅毒螺旋体颗粒凝集试验（teponema pallidum purtide assay，TPPA）检测，通过问卷收集已婚妊娠梅毒患者及其配偶的相关信息，采用多因素logistic回归模型分析配偶感染梅毒的影响因素。结果 本研究共纳入已婚妊娠梅毒患者及其配偶2 261对。接受调查的配偶中，528例TRUST和TPPA均阳性（23.35%），129例仅TPPA阳性（5.71%），配偶的梅毒感染率为29.06%（657/2 261）。妊娠梅毒患者血清滴度≥1：8、疾病诊断为早期梅毒和足量治疗后者其配偶感染梅毒的风险较高（均有P<0.05）。配偶文化水平在高中及以下、自身存在多性伴行为者其感染梅毒的风险较高（均有P<0.05）。结论 已婚妊娠梅毒患者的配偶具有较高的梅毒感染率，妊娠梅毒患者的梅毒血清滴度水平、疾病诊断情况以及配偶的多性伴行为等是影响配偶感染梅毒的重要因素。

Syphilis infection status and the associated factors among partners of married syphilis-infected pregnant women in Shenzhen

Objective To investigate syphilis infection status among partners of married syphilis-infected pregnant women, and analyze the associated factors from the perspective of both pregnant women and their partners. Methods Follow-up survey and contact tracing were conducted among married syphilis-infected pregnant women diagnosed from 2008 to 2011. Both toludine red unheated serum test (TRUST) and treponema pallidum particle agglutination (TPPA) were applied to partners attending antenatal care clinics. Structural questionnaires were used to collect information. Binary logistic regression model was applied to analyze the factors associated with partners' syphilis infection. Results Totally 2 261 pairs of married syphilis-infected pregnant women and their partners were recruited. Based on laboratory record, 528 partners were with positive results for both TRUST and TPPA (23.35%), and 129 partners were with positive results for only TPPA (5.71%), thus syphilis infection rate among partners were 29.06% (657/2 261). The partners were more likely to have syphilis infection when pregnant women were with TRUST titers ≥1:8, were with diagnosis of early syphilis or had received adequate treatment before pregnancy (all P<0.05). The partners had higher risk of syphilis infection when they had lower education level, or had multiple sex partners (all P<0.05). Conclusions Syphilis infection rate among partners of married syphilis-infected pregnant women is high. Pregnant women's levels of TRUST titer and disease stage as well as partners' sexual behaviors were important factors associated with partners' syphilis infection.