| 氟化钠对催乳素诱发分泌影响的体外研究 |
| |
| 引用本文： | 徐懿梅 袁淑德. 氟化钠对催乳素诱发分泌影响的体外研究[J]. 中国地方病学杂志, 1993, 12(6): 326-328 |
| |
| 作者姓名： | 徐懿梅 袁淑德 |
| |
| 作者单位： | 空军医学专科学校生理教研室，中国医科大学神经内分泌研究室，中国医科大学神经内分泌研究室 吉林市江南大街100号 |
| |
| 摘 要： | 应用半侧垂体培养和腺垂体原代单层细胞培养方法观察了ＮａＦ对ＰＲＬ基础分泌和ＴＲＨ、ＶＩＰ及ｍｅｔｏｃｌｏｐｒｉａｍｉｄｅ诱发分泌的影响。结果是：１、氟中毒大鼠半侧垂体ＴＲＨ诱发的ＰＲＬ分泌降低。２、ＮａＦ对腺垂体细胞ＰＲＬ基础分泌和ＴＲＨ、ＶＩＰ和ｍｅｔｏｃｌｏｐｒａｍｉｄｅ诱发分泌均具有抑制作用。提示氟中毒时氟化物可能通过对垂体的直接作用而抑制ＰＲＬ分泌。
|
| 关 键 词： | 催乳素 氟化物 血管活性肠肽 |
Studies of NaF on Prolactin Release in Rat in Vitro |
| |
| Xu Yimei,et al China Medical University Neuroendocrine Research Laboratory Shenyang. Studies of NaF on Prolactin Release in Rat in Vitro[J]. Chinese Jouranl of Endemiology, 1993, 12(6): 326-328 |
| |
| Authors: | Xu Yimei et al China Medical University Neuroendocrine Research Laboratory Shenyang |
| |
| Abstract: | Effects of NaF on PRL release in dispersed anterior pituitary cells were observed.The results were that PRLbasal release and induced secretion by TRH,VIP and metoclopramide were both reduced when added NaF in medi-um of anterior pituitary cells.The reaction of PRL release on TRH was also seen decreased in cultured semipitu-itary with fluorosis.Our results indicated that fluoride may directly affect pituitary cells to inhibit PRL secretion. |
| |
| Keywords: | prolactin NaF TRH VIP metoclopramide anterior pituitary cell culture |
| 本文献已被 CNKI 维普 等数据库收录！ |
