Genotypic analysis of large cell lymphomas which express the Ki-1 antigen |
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| Authors: | NTJ O'CONNOR H STEIN KC GATTER JS WAINSCOAT J CRICK T AL SAATI B FALINI G DELSOL DY MASON |
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| Institution: | MRC Unit of Molecular Haematology, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford;Institute of Pathology, Klinikum Steglitz, Free University of Berlin, West Germany;Nuffield Department of Pathology, John Radcliffe Hospital, Oxford;Department of Haematology, John Radcliffe Hospital, Oxford;Laboratoire Central d'Anatomie Pathologie, C.H.U. Toulouse Purpan, France;Istituto di Clinica Medica Generale e Terapia Medica, Policlinico Monteluce, Perugia, Italy |
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| Abstract: | The monoclonal antibody Ki-1 reacts with Reed-Sternberg cells in Hodgkin's disease and with the tumour cells in a minority of large cell non-Hodgkin's lymphomas. This study describes the results of immunophenotypic and DNA analysis in 30 cases of non-Hodgkin's lymphoma, all of which expressed the Ki-1 antigen. The genotypic analysis has been undertaken using both immunoglobulin and T-cell receptor gene probes. Sixteen cases were shown by this method to be of monoclonal T-cell origin, six of B-cell origin, while in eight cases there was no evidence of either T- or B-cell lineage. This confirms previous immunohistological data indicating that non-Hodgkin's lymphomas which express the Ki-1 antigen may be of either T-cell or B-cell origin. |
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| Keywords: | non-Hodgkin's lymphoma large cell Ki-1 antigen cell lineage |
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