| 体外循环中止血芳酸对血小板的保护作用 |
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| 引用本文： | 李军,王启松,路少林,马先宾,王强,赵宏伟. 体外循环中止血芳酸对血小板的保护作用[J]. 中华胸心血管外科杂志, 2001, 17(1): 27-28 |
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| 作者姓名： | 李军 王启松 路少林 马先宾 王强 赵宏伟 |
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| 作者单位： | 日照市人民医院心胸外科 |
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| 摘 要： | 目的：探讨止血芳酸在体外循环中对血小板的保护作用及其临床意义。方法：测定止血芳酸组和对照组血小板数量、出血量和输血量，及体外循环前后血浆α－颗粒膜蛋白（ＧＭＰ－１４０），血栓烷Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１a(6-k-PGF1a）的浓度变化。结果，体外循环术后血小板计数组明显高于对照组，出血量明显少于对照组。ＧＭＰ－１４０、ＴＸＢ２上升幅度小于对照组，二者相比差异显著（Ｐ＜０．０５）。结论：止血芳酸在体外循环术中可以起到保护血小板，减少术后出血的作用。
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| 关 键 词： | 止血药 止血芳酸 血小板 体外循环 保护作用 |
| 修稿时间： | 2000-08-21 |
Effect of acidium para-aminomethylben zoicum on platelet protection during cardiopulmonary bypass |
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| LI Jun,WANG Qisong,LU Shaolin,et al.. Effect of acidium para-aminomethylben zoicum on platelet protection during cardiopulmonary bypass[J]. Chinese Journal of Thoracic and Cardiovascular Surgery, 2001, 17(1): 27-28 |
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| Authors: | LI Jun WANG Qisong LU Shaolin et al. |
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| Affiliation: | LI Jun,WANG Qisong,LU Shaolin,et al. Department of Thoracic and Cardiac Surgery,Rizhao City Hospital,Rizhao 276800,China. |
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| Abstract: | Objective: To evaluate the effect of acidium para aminomethylben zoicum (PAMBA) on platelet protection during cardiopulmonary (CPB), and its clinical significance. Methods: Count of platelet, amount of blood loss and transfusion were recorded after CPB. GMP 140, TXB2 and 6 k PGF1a were assessed before and after CPB. Results: Count of platelet in PAMBA group was higher than that in control group (P< 0 05). Amount of blood loss in PAMBA group was significantly decreased than that in control group (P<0 05). The GMP 140 and TXB 2 in PAMBA group were lower than that in control group (P<0 05). Conclusion: PAMBA shows protective effect on platelet during CPB and reduces blood loss after open heart surgery. |
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| Keywords: | Hemostatics Acidium para aminomethylben zoicum Platelet Cardiopulmonary bypass |
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